A Novel Catalyst-Free Tandem Reaction for the Synthesis of 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones in Water Medium

Ming-Yu Wu, Kun Li, Na Wang, Ting He & Xiao-Qi Yu
A novel catalyst-free, water-medium, tandem reaction for the synthesis of 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was developed through a one-pot strategy from nitroethylenes and 1,3-dicarbonyl compounds. A series of 1-aryl-2-nitroethenes and 1-nitroalk-1-enes were surveyed to determine the scope of this tandem reaction with moderate to good yield.
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