Stability study of parabens in pharmaceutical formulations containing Paracetamol or Carbocisteine by high-performance liquid chromtatography

Miloud EL Karbane, Aziz ELalami, Houda Bouchafra, Houda Bourichi, Yahia Cherrah, Mohamed Azougagh & Abdelaziz Bouklouze
A new, simple, specific, sensitive, rapid, accurate and precise RP-HPLC method was developed for the proportioning of the methylparaben and the propylparaben in pharmaceutical formulations as well as the phenol, which is their main degradation product. These parabens are widely used as preservatives in pharmaceutical and cosmetic products. The separation was performed on a C18-column using a mobile phase elution gradient (Acetate buffer 50mM pH 5/Acetonitrile). The detection was performed at a fixed wavelength (l...
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