Synthesis and antibacterial screening of novel 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives

Ramesh Mahadev Shingare, Yogesh S Patil, Suchita Gadekar, Jaiprakash N Sangshetti & Balaji R Madje
Novel 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives like 5-(2,4-Dichlorophenyl)-3-(3-fluoro-4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (3a-p) were synthesized from 3-fluoro-4-methoxy acetophenone and screened for their antibacterial activity. Chalcones (2a-f) prepared by condensation of 3-fluoro-4-methoxy acetophenone with different aromatic aldehydes were reacted with phenyl hydrazine hydrate or substituted phenyl hydrazine to obtain 1,3,5-triaryl-4,5-dihydro-1H-pyrazole (3a-p). Structures of the synthesized 1,3,5-triary-4,5-dihydro-1H-pyrazole compounds (3a-p) were characterized using IR, 1H NMR, 13C NMR, MS spectral data. All synthesized compounds screened for their antibacterial activity against E. Coli, P. aeruginosa, S....
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