A novel route to 1,4-dihydroquinoxaline for biological and electrochemical properties

A. Zouitini, Y. Kandri Rodi, H. Elmsellem, F. Ouazzani Chahdi, K. Misbahi, A. E. Janati, Y. Ouzidan, M. Akhazzane & E. M. Essassi
In this paper we describe the synthesis of new quinoxalines which can present a potential pharmacological properties The 6-methyl-1,4-dihydroquinoxaline-2,3-dione 3 was synthesized by the condensation of 4-methyl-o-phenylenediamine 1 with oxalic acid 2 under reflux in hydrochloric acid solution.Compound3 was exposed to alkylation reactions under the conditions of phase transfer catalysis using monohalogenated agents leading to alkylated products 3a-3f. Structures of the obtained products were confirmed by spectroscopic measurements.
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