EVALUATION OF THE EFFECTS OF GLYCOSAMINOGLYCANS ON THE ACTIVITY OF CYSTEINE PROTEASE CATHEPSIN INHIBITORS

WAGNER ALVES DE SOUZA JÚDICE
Cathepsins B and L, cysteine ​​lysosomal proteases, are important targets in the development of a variety of therapeutic agents due to the involvement of these proteases in various disease conditions. They are associated with cancer progression due to the degradation capacity of the extracellular matrix, facilitating invasion, angiogenesis and metastasis, in addition to favoring viral replication in human cells. Studies suggest that GAGs play a key role in cell signaling, which serves to modulate a...
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