Our group recently observed that male mice containing a deletion for the gene encoding the thiol oxidoreductase glutaredoxin-2 (GRX2) were protected from diet-induced obesity (DIO) and the development of related disorders (e.g. fatty liver disease). This effect was associated with increased fuel combustion in muscles. In the present study, I assessed if deleting the Grx2 gene protected female mice from DIO. Unlike male mice, in this study female wild-type (WT) littermates were completely resistant to...