The effects of chronic hypoxia and nitric oxide on myocardial contractility in steelhead trout (Onchorhynchus mykiss)

Environmental hypoxia has been intensifying and spreading in recent years due to climate change, and there is accumulating evidence that the cardiac function of hypoxia-intolerant fish is negatively affected by long-term exposure to low oxygen conditions. However, the cause of this reduced heart performance has not been conclusively identified, and it is unknown whether nitric oxide (NO)-mediated effects are involved. This thesis examined how chronic hypoxia (> 8 weeks at ~8 kPa O₂) influenced the...
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