Molecular chaperones are crucial machines that maintain protein homeostasis in the cell. In the ER, the two major chaperones performing this function are the Hsp70 BiP and Hsp90 Grp94. While BiP interacts with every nascent polypeptide targeted to the ER and has a specific client binding motif, less is known about how Grp94 chooses its clients. Here, I explore how BiP and Grp94 can work together and set the groundwork for studies exploring a shared...