Impact of Dopamine Synthesis Capacity in Midbrain Regions of Interest on Cognitive Stability and Flexibility in Older Adults

Rebekah Fain
In aging, we see marked alterations to the dopamine system, specifically with losses in the number of dopamine receptors and transporters and increases in dopamine synthesis capacity. While striatal dopamine has been a focus of research, midbrain synthesis capacity has been less thoroughly explored. Here, we developed a protocol that allowed us to accurately define and measure midbrain dopamine synthesis capacity, specifically in the substantia nigra and ventral tegmental area. Using the positron emission tomography...
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