Spectrum of Chromosomal Repair Mutations Associated with Mitotic Gene Conversions

Qiying Cui
The genome of a cell is continuously subject to damage. By-products from cell metabolism, irradiation, chemical agents, and ultraviolet light are all environmental factors that cause lesions that can block replication progression. Although cells have adapted checkpoint mechanisms and repair pathways, repair failure can lead to deletions, translocations, and fusions in the DNA. These genomic rearrangements are commonly found in cancer cells. Double-strand breaks (DSBs) are problematic and the most lethal type of damage if...
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