Data from: Fisher’s geometrical model and the mutational patterns of antibiotic resistance across dose gradients

Noémie Harmand, Romain Gallet, Roula Jabbour-Zahab, Guillaume Martin & Thomas Lenormand
Fisher's geometrical model (FGM) has been widely used to depict the fitness effects of mutations. It is a general model with few underlying assumptions that gives a large and comprehensive view of adaptive processes. It is thus attractive in several situations, e.g. adaptation to antibiotics, but comes with limitations, so that more mechanistic approaches are often preferred to interpret experimental data. It might be possible however to extend FGM assumptions to better account for mutational...
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