The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney

Daniel Fuster, Manuel Anderegg, Giuseppe Albano, Daniela Hanke, Christine Deisl, Dominik E. Uehlinger, Simone Brandt, Rajesh Bhardwaj & Matthias A. Hediger
NHA2 is sodium/hydrogen exchanger that was associated with arterial hypertension in humans, but the role of NHA2 in kidney function and blood pressure homeostasis is currently unknown. Here we show that NHA2 localizes almost exclusively to distal convoluted tubules in the kidney. NHA2 knock-out mice displayed reduced blood pressure, normocalcemic hypocalciuria and an attenuated response to the thiazide diuretic hydrochlorothiazide. Phosphorylation of the thiazide-sensitive sodium/chloride cotransporter NCC and its upstream activating kinase Ste20/SPS1-related proline/alaninerich kinase...
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