Population-level variation in parasite resistance due to differences in immune initiation and rate of response

Amanda Hund, Lauren Fuess, Mariah Kenney, Meghan Maciejewski, Joseph Marini, Kum Chuan Shim & Dan Bolnick
Closely related populations often differ in resistance to a given parasite, as measured by infection success or failure. Yet, the immunological mechanisms of these evolved differences are rarely specified. Does resistance evolve via changes to the host’s ability to recognize that an infection exists, actuate an effective immune response, or attenuate that response? We tested whether each of these phases of the host response contributed to threespine sticklebacks’ recently evolved resistance to their tapeworm Schistocephalus...
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