Colorectal cancer interleukin-10 blockade scRNA-seq

Christopher Lausted, Kevin Sulllivan, Xiuyun Jiang, Prajna Guha, Jason Carter, Cynthia Hsu, Kevin Labadie, Karen Kohli, Heidi Kenerson, Sara Daniel, Xiaowei Yan, Changting Meng, Stella Shin, Arezou Abbasi, David Seo, James Park, Nicholas Crispe, Taranjit Gujral, Raymond Yeung, Teresa Kim, Qiang Tian, Steven Katz & Venu Pillarisetty
Objective: PD-1 checkpoint inhibition and adoptive cellular therapy have limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We demonstrate that interleukin-10 (IL-10) blockade enhances endogenous T cell and chimeric antigen receptor T (CAR-T) cell anti-tumor function in CRLM slice cultures.Design: We created organotypic slice cultures from human CRLM (n = 38) and tested the anti-tumor effects of a neutralizing antibody against IL-10 (αIL-10). We evaluated slice cultures with single and multiplex...
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