Single cell Iso-Sequencing enables rapid genome annotation for scRNAseq analysis

Hope Healey, Susan Bassham & William Cresko
Single cell RNA sequencing (scRNAseq) is a powerful technique that continues to expand across various biological applications. However, incomplete 3’ UTR annotations can impede single cell analysis resulting in genes that are partially or completely uncounted. Performing scRNAseq with incomplete 3’ UTR annotations can hinder the identification of cell identities and gene expression patterns and lead to erroneous biological inferences. We demonstrate that performing single cell isoform sequencing (ScISOr-Seq) in tandem with scRNAseq can rapidly...
1 citation reported since publication in 2022.
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