Data from: Peptides derived from cadherin juxtamembrane region inhibit platelet function

Kalyan Golla, Ilias Stavropoulos, Denis Shields, Nimah Moran, Denis C. Shields & Niamh Moran
The juxtamembrane domains (JMD) of transmembrane proteins are rich in critical peptide sequences that participate in dynamic cell signaling events. Synthetic JMD peptides derived from cadherin cell adhesion proteins have previously been shown to modulate platelet function. In this study, we aimed to develop functional bioactive agents from bioinformatically-identified critical peptide sequences. We synthesized overlapping 12-15 amino acids peptides from E- and N-cadherin JMD and assessed their effect on platelet aggregation and platelet ATP secretion....
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