Data from: Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells

Rahul Sampath, Nathan W. Cummins, Sekar Natesampillai, Gary D. Bren, Thomas D. Chung, Jason Baker, Keith Henry, Amelie Pagliuzza & Andrew D. Badley
HIV persists because a reservoir of latently infected CD4 T cells do not express viral proteins and are indistinguishable from uninfected cells. One approach to HIV cure suggests that reactivating HIV will activate cytotoxic pathways; yet when tested in vivo, reactivating cells do not die sufficiently to reduce cell-associated HIV DNA levels. We recently showed that following reactivation from latency, HIV infected cells generate the HIV specific cytotoxic protein Casp8p41 which is produced by HIV...
1 citation reported since publication in 2017.
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