Ions release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: In vitro experiments and theoretical modelling study

Maria Tomoaia-Cotisel, Aurora Mocanu, Oana Cadar, Petre Frangopol, Ioan Petean, Gheorghe Tomoaia, Gertrud-Alexandra Paltinean, Csaba Pall Racz & Ossi Horovitz
The multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more consideration due to their multifunctional properties and biomimetic structure, owning thus an enhanced biological potential in orthopedic and dental applications. In this study, nano hydroxyapatite (HAP) substituted with multiple cations (Sr2+, Mg2+ and Zn2+) for Ca2+ and anion (SiO44-) for PO43- and OH-, specifically HAPc-5%Sr and HAPc-10%Sr (where HAPc is HAP-1.5%Mg-0.2%Zn-0.2%Si), both lyophilized noncalcined and lyophilized calcined, were evaluated for their in vitro ions release. These nanomaterials...
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