Data from: Fat, fibre and cancer risk in African Americans and rural Africans

Stephen J. D. O’Keefe, Jia V. Li, Leo Lahti, Junhai Ou, Franck Carbonero, Mohammed Khaled, Joram M. Posma, James Kinross, Elaine Wahl, Elizabeth Ruder, Kishore Vipperla, Vasudevan Naidoo, Lungile Mtshali, Sebastian Tims, Philippe G. B. Puylaert, James DeLany, Alyssa Krasinskas, Ann C. Benefiel, Hatem O. Kaseb, Keith Newton, Jeremy K. Nicholson, Willem M. De Vos, H. Rex Gaskins & Erwin G. Zoetendal
Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in...
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