Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

Joseph Giovinazzo, Joseph A Giovinazzo, Russell P Thomson, Nailya Khalizova, Patrick Zager, Nirav Malani, Enrique Javier Rodriguez-Boulan, Jayne Raper & Ryan Schreiner
Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, causing lysis. While the correlation to kidney disease is robust, there is little consensus concerning the underlying disease mechanism. We show in human cells that the APOL1 renal risk variants have a population of active channels at...
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