Barcoded Bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

Alex N. Nguyen Ba, Katherine Lawrence, Artur Rego-Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor & Michael Desai
Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability in many traits, allowing us to predict phenotype from genotype. However, constraints on power due to statistical confounders in large GWAS and smaller sample sizes in QTL studies still limit our ability...
1 citation reported since publication in 2021.
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