Data from: Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Vimal Parkash, Yashraj Kulkarni, Josy Ter Beek, Polina V. Shcherbakova, Shina C. L. Kamerlin & Erik Johansson
The most frequently recurring cancer-associated DNA polymerase ε (Pol ε) mutation is a P286R substitution in the exonuclease domain. While originally proposed to increase genome instability by disrupting exonucleolytic proofreading, the P286R variant was later found to be significantly more pathogenic than Pol ε proofreading deficiency per se. The mechanisms underlying its stronger impact remained unclear. Here we report the crystal structure of the yeast orthologue, Pol ε−P301R, complexed with DNA and an incoming dNTP....
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