Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load

Antoine Leuzy, Johan Lilja, Christopher Buckley, Rik Ossenkoppele, Sebastian Palmqvist, Mark Battle, Gill Farrar, Dietmar Thal, Shorena Janelidze, Erik Stomrud, Olof Strandberg, Ruben Smith & Oskar Hansson
Abstract Objective: To evaluate a novel Aβ-PET based quantitative measure (Aβ accumulation index [Aβ-index]), including the assessment of its ability to discriminate between subjects based on Aβ-status using visual-read, CSF Aβ42/Aβ40 and post-mortem neuritic-plaque burden as standards of truth. Methods: 1121 subjects (with and without cognitive impairment) scanned with Aβ-PET: Swedish BioFINDER, n=392, [18F]flutemetamol; ADNI, n=692, [18F]florbetapir; a phase-3 end-of-life study, n=100, [18F]flutemetamol). The relationships between Aβ-index and standardized uptake values ratios (SUVR) from Aβ-PET...
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