Tuning cell behavior with nanoparticle shape

Loris Rizzello, Alessandro Poma, Eva Liatsi-Douvitsa, Giuseppe Battaglia, Valeria De Matteis, Cesare De Pace, Adrian Joseph, Claudia Contini, Edoardo Scarpa, Josep Martí, Loris Rizzello & Senio De Souza
We investigated how the shape of polymeric vesicles, made by the exact same material, impacts the replication activity and metabolic state of both cancer and non-cancer cell types. First, we isolated discrete geometrical structures (spheres and tubes) from a heterogeneous sample using density-gradient centrifugation. Then, we characterized the cellular internalization and the kinetics of uptake of both types of polymersomes in different cell types (either cancer or non-cancer cells). We also investigated the cellular metabolic...
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