Data from: Gene duplication and co-evolution of G1/S transcription factors specificity in fungi are essential for optimizing cell fitness

Adi Hendler, Edgar M. Medina, Anastasiya Kishkevich, Mehtap Abu-Qarn, Steffi Klier, Nicolas E. Buchler, Robertus A. M. De Bruin & Amir Aharoni
Transcriptional regulatory networks play a central role in optimizing cell survival. How DNA binding domains and cis-regulatory DNA binding sequences have co-evolved to allow the expansion of transcriptional networks and how this contributes to cellular fitness remains unclear. Here we experimentally explore how the complex G1/S transcriptional network evolved in the budding yeast Saccharomyces cerevisiae by examining different chimeric transcription factor (TF) complexes. Over 300 G1/S genes are regulated by either one of the two...
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