Anti-seizure medication use during pregnancy and risk of ASD and ADHD in children

Kelsey Wiggs, Martin Rickert, Ayesha Sujan, Patrick Quinn, Henrik Larsson, Paul Lichtenstein, Sara Oberg & Brian D'Onofrio
Objective: To determine whether children born to women who use anti-seizure medications (ASMs) during pregnancy have higher risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) independent of confounding factors. Methods: We used Swedish-register data (n=14,614 children born 1996-2011 and followed through 2013) to examine associations in children of women with epilepsy, using the largest sample to date and adjusting for a range of measured confounders. We examined maternal-reported first-trimester use of any ASM...
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