Data from: Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture

Ryan O. Emerson, James M. Mathew, Iwona M. Konieczna, Harlan S. Robins & Joseph R. Leventhal
The cellular immune response is the most important mediator of allograft rejection and is a major barrier to transplant tolerance. Delineation of the depth and breadth of the alloreactive T cell repertoire and subsequent application of the technology to the clinic may improve patient outcomes. As a first step toward this, we have used MLR and high-throughput sequencing to characterize the alloreactive T cell repertoire in healthy adults at baseline and 3 months later. Our...
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