Data from: Experimental manipulation of population-level MHC diversity controls pathogen virulence evolution in Mus musculus

Douglas H. Cornwall, Jason L. Kubinak, Elisabeth Zachary, Derek L. Stark, Dustan Seipel & Wayne K. Potts
The virulence levels attained by serial passage of pathogens through similar host genotypes are much higher than observed in natural systems, however, it is unknown what keeps natural virulence levels below these empirically demonstrated maximum levels. One hypothesis suggests that host diversity impedes pathogen virulence, because adaptation to one host genotype carries tradeoffs in the ability to replicate and cause disease in other host genotypes. To test this hypothesis, with the simplest level of population...
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