The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins

Andrew W McCracken, Gracie Adams, Laura Hartshorne, Marc Tatar & Mirre J. P. Simons
Dietary restriction (DR) extends life span across taxa. Despite considerable research, universal mechanisms of DR have not been identified, limiting its translational potential. Guided by the conviction that DR evolved as an adaptive, pro-longevity physiological response to food scarcity, biomedical science has interpreted DR as an activator of pro-longevity molecular pathways. Current evolutionary theory predicts that organisms invest in their soma during DR, and thus when resource availability improves, should outcompete rich-fed controls in survival...
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