Data from: Cyclin dependent kinase 5 (CDK5) regulates the circadian clock

Andrea Brenna, Iwona Olejniczak, Rohit Chavan, Jürgen Ripperger, Sonja Langmesser, Elisabetta Cameroni, Zehan Hu, Claudio De Virgilio, Jörn Dengjel & Urs Albrecht
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. We observed that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian clock involving phosphorylation of PER2. Knock-down of Cdk5 in the suprachiasmatic nuclei (SCN), the...
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