Time course and diagnostic utility of NfL, tau, GFAp, and UCH-L1 in subacute and chronic TBI

Pashtun Shahim, Adam Politis, Andre Van Der Merwe, Brian Moore, Vindhya Ekanayake, Sara Lippa, Yi-Yu Chou, Dzung Pham, John Butman, Ramon Diaz-Arrastia, Henrik Zetterberg, Kaj Blennow, Jessica Gill, David Brody & Leighton Chan
Objective: To determine whether neurofilament light (NfL), glial fibrillary acidic protein (GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor imaging (DTI) measures of traumatic axonal injury (TAI) in patients with TBI. Methods: Patients with TBI (n = 162) and controls (n = 68) were prospectively enrolled between 2011 and 2019. Patients with TBI also underwent serum, functional outcome, and...
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