Salamanders reveal novel trajectories of amphibian MHC evolution

Piotr Minias, Gemma Palomar, Katarzyna Dudek & Wiesław Babik
Genes of the Major Histocompatibility Complex (MHC) code for immune proteins that are crucial for pathogen recognition in vertebrates. MHC research in non-model taxa has long been hampered by its genomic complexity that makes the locus-specific genotyping challenging. The recent progress in sequencing and genotyping methodologies allows an extensive phylogenetic coverage in studies of MHC evolution. Here, we analysed the peptide-binding region of MHC class I in 30 species of salamanders from six families representative...
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