Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

Adelaida M. Celaya, Isabel Sánchez-Pérez, Jose M. Bermúdez-Muñoz, Lourdes Rodríguez-De La Rosa, Laura Pintado-Berninches, Rosario Perona, Silvia Murillo-Cuesta & Isabel Varela-Nieto
Mitogen-activated protein kinases (MAPK) p38 and c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. Stress kinases are well-described elements of the response to otic injury and the otoprotective potential of JNK inhibitors is being tested in clinical trials. In contrast, there are no studies exploring the role of DUSP1 in hearing and hearing loss....
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