Data from: Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis

Lucas Di Meglio, Jean-Philippe Desilles, Veronique Ollivier, Mialitiana Solo Nomenjanahary, Sara Di Meglio, Catherine Deschildre, Stephane Loyau, Jean-Marc Olivot, Raphael Blanc, Michel Piotin, Marie-Christine Bouton, Jean-Baptiste Michel, Martine Jandrot-Perrus, Benoit Ho-Tin-Noé & Mikael Mazighi
Objectives. Thrombi responsible for large vessel occlusion (LVO) in the setting of acute ischemic stroke (AIS) are characterized by a low recanalization rate after intravenous thrombolysis. To test whether AIS thrombi have inherent common features that limit their susceptibility to thrombolysis, we analyzed the composition and ultrastructural organization of AIS thrombi causing LVO. Methods. A total of 199 endovascular thrombectomy-retrieved thrombi were analyzed by immunohistology, scanning electron microscopy (SEM), and subjected to ex vivo thrombolysis...
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