Data from: De novo active sites for resurrected Precambrian enzymes

Valeria A. Risso, Sergio Martinez Rodriguez, Adela M. Candel, Dennis M. Krüger, David Pantoja-Uceda, Mariano Ortega-Munoz, Francisco Santoyo-Gonzalez, Eric A. Gaucher, Shina Caroline Lynn Kamerlin, Marta Bruix, Jose A. Gavira & Jose M. Sanchez-Ruiz
Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed many different reactions already in the last universal common ancestor. Mechanisms for the emergence of completely new active sites must therefore either plausibly exist or at least have existed at the primordial protein stage. Here, we use resurrected Precambrian proteins as scaffolds for protein engineering and demonstrate that a new active site can be generated...
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