Cortical microstructural correlates of astrocytosis in autosomal dominant Alzheimer disease

Eduard Vilaplana, Elena Rodriguez-Vieitez, Daniel Ferreira, Victor Montal, Ove Almkvist, Anders Wall, Alberto Lleo, Eric Westman, Caroline Graff, Juan Fortea & Agneta Nordberg
Objective To study the macrostructural and microstructural MRI correlates of brain astrocytosis, measured with 11C-deuterium-L-deprenyl (11C-DED)–PET, in familial autosomal dominant Alzheimer disease (ADAD). Methods The total sample (n = 31) comprised ADAD mutation carriers (n = 10 presymptomatic, 39.2 ± 10.6 years old; n = 3 symptomatic, 55.5 ± 2.0 years old) and noncarriers (n = 18, 44.0 ± 13.7 years old) belonging to families with mutations in either the presenilin-1 or amyloid precursor protein...
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