Data from: Elovanoids counteract oligomeric β-Amyloid-induced gene expression and protect photoreceptors

Nicolas Bazan, Khanh Do, Marie-Audrey Kautzmann, Bokkyoo Jun, William Gordon, Robert Nshimiyimana, Rong Yang & Nicos Petasis
The onset of neurodegenerative diseases activates inflammation that leads to progressive neuronal cell death and impairments in cognition (Alzheimer’s disease, AD) and sight (age-related macular degeneration, AMD). How neuroinflammation can be counteracted is not known. In AMD, amyloid β-peptide (Aβ) accumulates in subretinal drusen. In the 5xFAD retina, we found early functional deficiencies (ERG) without photoreceptor cell (PRC) death and identified early insufficiency in biosynthetic pathways of pro-homeostatic/neuroprotective mediators, neuroprotectin D1 (NPD1) and elovanoids (ELVs)....
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