Data from: The basis of antagonistic pleiotropy in hfq mutations that have opposite effects on fitness at slow and fast growth rates

Thomas Ferenci, Ram Maharjan, Christopher McKenzie & Anna Yeung
Mutations beneficial in one environment may cause costs in different environments, resulting in antagonistic pleiotropy. Here we describe a novel form of antagonistic pleiotropy that operates even within the same environment, where benefits and deleterious effects exhibit themselves at different growth rates. The fitness of hfq mutations in Escherichia coli affecting the RNA chaperone involved in small-RNA regulation is remarkably sensitive to growth rate. E. coli populations evolving in chemostats under nutrient limitation acquired beneficial...
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