Data from: CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer's disease

Shorena Janelidze, Niklas Mattsson, Erik Stomrud, Olof Lindberg, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow & Oskar Hansson
Objective: To measure cerebrospinal (CSF) levels of biomarkers reflecting microglia and astrocytes activation, neuroinflammation and cerebrovascular changes and study their associations with the core biomarkers of AD pathology (amyloid &[beta] (A&[beta]) and tau), structural imaging correlates and clinical disease progression over time. Methods: The study included cognitively unimpaired elderly (n=508), patients with mild cognitive impairment (MCI, n=256), and AD dementia (n=57) from the longitudinal Swedish BioFINDER cohort. CSF samples were analyzed for YKL-40, IL-6, IL-7,...
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