Antibiotics and dietary habits can affect the gut microbial community, influencing disease susceptibility. Although the influence of microbiota on the postnatal environment has been well documented, much less is known regarding the impact of gut microbiota at the embryonic stage. Here, we show that maternal microbiota shapes the metabolic system of offspring. During pregnancy, short-chain fatty acids produced by the maternal microbiota dictate the differentiation of neural, intestinal, and pancreatic cells through embryonic GPR41 and...