Data from: The mammalian complement system as an epitome of host–pathogen genetic conflicts

Rachele Cagliani, Diego Forni, Giulia Filippi, Alessandra Mozzi, Luca De Gioia, Chiara Pontremoli, Uberto Pozzoli, Nereo Bresolin, Mario Clerici & Manuela Sironi
The complement system is an innate immunity effector mechanism; its action is antagonized by a wide array of pathogens and complement evasion determines the virulence of several infections. We investigated the evolutionary history of the complement system and of bacterial-encoded complement-interacting proteins. Complement components targeted by several pathogens evolved under strong selective pressure in primates, with selection acting on residues at the contact interface with microbial/viral proteins. Positively selected sites in CFH and C4BPA account...
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