Brain aromatase and the regulation of sexual activity in male mice

David C. Brooks, John S. Coon V, Cihangir M. Ercan, Xia Xu, Hongxin Dong, Jon E. Levine, Serdar E. Bulun & Hong Zhao
The biologically active estrogen, estradiol, has important roles in adult brain physiology and sexual behavior. A single gene, Cyp19a1, encodes aromatase, the enzyme that catalyzes the conversion of testosterone to estradiol in the testis and brain of male mice. Estradiol formation was shown to regulate sexual activity in various species, but the relative contributions to sexual behavior of estrogen arising in the brain versus gonads remained unclear. To determine the role of brain aromatase in...
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