Data from: Negative epistasis between beneficial mutations in an evolving bacterial population

Aisha I Khan, Duy M Dinh, Dominique Schneider, Richard E Lenski & Tim F Cooper
Epistatic interactions between mutations play a prominent role in evolutionary theories. Many studies have found that epistasis is widespread, but they have rarely considered beneficial mutations. We analyzed the effects of epistasis on fitness for the first five mutations to fix in an experimental population of Escherichia coli. Epistasis depended on the effects of the combined mutations—the larger the expected benefit, the more negative the epistatic effect. Epistasis thus tended to produce diminishing returns with...
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