Data from: The translational landscape of the splicing factor SRSF1 and its role in mitosis

Magdalena M. Maslon, Sara R. Heras, Nicolas Bellora, Eduardo Eyras & Javier F. Cáceres
The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally regulated by SRSF1, we performed a high-throughput deep sequencing analysis of polysomal fractions in cells overexpressing SRSF1. We identified approximately 1,500 mRNAs that are translational targets of SRSF1. These include mRNAs encoding proteins involved in cell cycle regulation, such as spindle, kinetochore and...
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