Datasets for: The HIV-1 viral protease is activated during assembly and budding prior to particle release

Caroline Tabler, Sarah Wegman, Jiji Chen, Hari Shroff, John Tilton & Najwa Alhusaini
HIV-1 encodes a viral protease that is essential for the maturation of infectious viral particles. While protease inhibitors are effective antiretroviral agents, recent studies have shown that prematurely activating – rather than inhibiting – protease function leads to the pyroptotic death of infected cells, with exciting implications for efforts to eradicate viral reservoirs. Despite 40 years of research into the kinetics of protease activation, it remains unclear exactly when protease becomes activated. Recent reports have...
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