Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Jamie Vandenberg, Sara Ballouz, Melissa M Mangala, Matthew D Perry, Stewart Heitmann, Jesse A Gillis, Adam P Hill & Jamie I Vandenberg
Abstract Aims Cardiac electrical activity is extraordinarily robust. However, when it goes wrong it can have fatal consequences. Electrical activity in the heart is controlled by the carefully orchestrated activity of more than a dozen different ion conductances. Whilst there is considerable variability in cardiac ion channel expression levels between individuals, studies in rodents have indicated that there are modules of ion channels whose expression co-vary. The aim of this study was to investigate whether...
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