Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby

Keith Weninger, Pengyu Hao, Sharonda J. LeBlanc, Brandon C. Case, Timothy C. Elston, Manju M. Hingorani & Dorothy A. Erie
DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp that no longer recognizes the mismatch. Little is known about the postrecognition MutS mobile clamp and its interactions with MutL. Two disparate frameworks have been proposed: One in which MutS–MutL...
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