Frequency of biologically-defined AD in relation to age, sex, APOEε4 and cognitive impairment in a prospective cohort study

Joseph Therriault, Tharick Pascoal, Andrea Benedet, Jaime Fernandez-Arias, Tina Wang, Gleb Berzgin, Min Su Kang, Firoza Lussier, Mira Chamoun, Melissa Savard, Cecile Tissot, Gassan Massarweh, Jean-Paul Soucy, Paolo Vitali, Paramita Saha-Chaudhuri, Serge Gauthier & Pedro Rosa-Neto
Objective: To assess the frequency of biologically-defined Alzheimer’s disease (AD) in relation to age, sex and APOEε4, as well as rates of discordance between clinically- and biologically defined AD. Methods: We assessed cognitively unimpaired (CU) elderly (n=166), amnestic MCI (n=77) and probable AD dementia (n=62) subjects who underwent evaluation by dementia specialists and neuropsychologists in addition to amyloid-PET with [18F]AZD4694 and tau-PET with [18F]MK6240. Individuals were grouped according to their AD biomarker profile. Positive predictive...
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