A liposome assay showing the absence of scrambling in TTYH proteins and a lipidomics analysis of TTYH2

Anastasiia Sukalskaia & Raimund Dutzler
The Tweety homologues (TTYHs) are members of a conserved family of eukaryotic membrane proteins that are abundant in the brain. The three human paralogs were assigned to function as anion channels that are either activated by Ca2+ or cell swelling. To uncover their unknown architecture and its relationship to function, we have determined the structures of human TTYH1–3 by cryo-electron microscopy. All structures display equivalent features of a dimeric membrane protein that contains five transmembrane...
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