Data from: Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Alenka Guček, Nikhil R. Gandasi, Muhmmad Omar-Hmeadi, Marit Bakke, Stein O. Døskeland, Anders Tengholm & Sebastian Barg
Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like insulin requires further expansion of the pore. There is evidence that pore expansion is regulated and can fail in diabetes and neurodegenerative disease. Here we report that the cAMP-sensor Epac2 (Rap-GEF4) controls fusion pore behavior by acutely recruiting two pore-restricting proteins, amisyn and dynamin-1,...
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